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Current and Emerging Therapies in Advanced Colorectal Cancer (eBook)

£34.95

Advances in Medicine

Editor in Chief: Fortunato Ciardiello

There is a large unmet patient need in advanced colorectal cancer and a need for timely and effective treatments. Current and Emerging Therapies in Advanced Colorectal Cancer has been developed to raise awareness and education healthcare professionals on changes to the treatment paradigm due to the arrival of a new generation of targeted therapies which offer a more personalised approach to treatment and therefore improve patient outcomes..

This chapter based book discusses the role of an effective multidisciplinary team patient management in the management of advanced colorectal patients together with a chapter on surgery and a discussed of available medical and non-medical treatments.

 

 

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Product Description

CONTENTS

AUTHOR BIOGRAPHIES

PREFACE

CHAPTER 1: INTRODUCTION TO COLORECTAL TUMOR MANAGEMENT

  • Epidemiology
  • Pathogenesis
  • Screening
  • Clinical presentation
  • Diagnosis
  • Staging
  • Current and future treatment options

CHAPTER 2 – THE CHANGING TREATMENT PARADIGM IN ADVANCED COLORECTAL CANCER

  • Emerging role of targeted therapies
  • The changing treatment paradigm in advanced colorectal cancer
  • Drug targets and signal pathways- what new research tells us
  • Predictive and prognostic factors of response to targeted therapy
  • Towards individualized care in colorectal cancer management

CHAPTER 3: PATIENT CENTRED MANAGEMENT OF ADVANCED COLORECTAL CANCER

  • Towards a personalized medicine in advanced colorectal cancer management
    • Unmet patient needs in advanced colorectal cancer and current and future expectation from treatment
    • Management approach: The care pathway
    • Optimizing treatment outcomes
  • The importance of a multidisciplinary team approach
  • The core team and discussion of roles
    • Specialist surgeons and hepatobiliary surgeon
    • Clinical Oncologist
    • Medical Oncologist
    • Diagnostic radiologist with gastro-intestinal expertise.
    • Histopathologist.
    • Skilled colonoscopist of any discipline (surgeon, physician, or specialist nurse).
    • Clinical nurse specialists (CNSs)
    • Palliative care specialist (doctor or nurse), who should work with palliative care services in the community
    • Other support workers such as social

CHAPTER 4: THE KEY ROLE OF THE SURGEON AND SURGICAL ADVANCES IN CRC INTERVENTION

  • Curative role of surgery
    o Importance of early surgical intervention and referral in CRC
  • Key role of surgeon in the multidisciplinary team (referral to pathologist, further surgery)
  • Types of surgery and tumor types e.g.
    • Total mesenteric excision (TME)
    • Keyhole bowel surgery
  • Surgery for hepatic metastases
    • liver resection as potentially curative in mCRC
  • Role of pre and post-operative chemotherapy (especially targeted therapies)
  • RECIST
  • Surgery to improve overall survival outcomes in mCRC
  • Total mesorectal excision for rectal cancer: endoscopic trans anal proctectomy (ETAP)

CHAPTER 5: NEWER DRUGS AND KEY CLINICAL TRIALS

  • Changing landscape of treatment – new drugs on the horizon for CRC in 2016 and beyond and key clinical trials
  • Targeted chemotherapy
    • Regorafenib, CORRECT trial
    • Ziv-aflibercept, VELOUR, AFFIRM trials
    • Perifosine- XPECT trial
    •  Erlotinib- DREAM (OPTIMOX 3) trial
    • Bevacizumab continued beyond progression
    • Aflibercept
    • Cetuximab
    • Panitumumab
    • Trifluridine-tipiracil
  • First line Combination Therapies for Advanced Colorectal Cancer
    • Oxaliplatin plus flurouracil (FU) and leucovorin (referred to as FOLFOX)
    • Irinotecan plus FU and leucovorin (referred to as FOLFIRI)
    • Oxaliplatin plus capecitabine  (referred to as XELOX or CAPOX)

CHAPTER 6: FUTURE PERSPECTIVES

  • At a Glance Expert Overview

REFERENCES

APPENDIX 1: ABBREVIATIONS

APPENDIX 2: KEY GUIDELINES (e.g. NICE, ESMO 2014, ASCO)

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